The impace of custom ROM backups on android external storage erasure

The Android operating system is the current market leader on mobile devices such as smartphones and tablet computers. The core operating system is open source and has a number of developers creating variants of this operating system. These variants, often referred to as custom ROMs are available for a wide number of mobile devices. Custom ROMs provide a number of features, such as enhanced control over the operating system, variation in user interfaces and so on. The process of installing custom ROMs is often accomplished through the use of a ROM manager application. Such applications often provide mechanisms to back up the contents of the mobile device prior to upgrade. This mechanism is utilised in the case of a failed update to restore the device to its previous functional state. Backups produced in this manner are often stored in on an external media such as a micro-SD card.In the conducted research we evaluated devices inbuilt data erasure mechanisms within the context of erasure of backups produced by ROM managers. It was found that simply using the devices Format External / SD function is not an effective means of completely erasing these backups. Once recovered, these backups offer a quick source of information that a potential attacker could carve to retrieve user files such as media transferred to the external or from applications. Although the same files could be recovered from an image of the external storage itself, the carving process is more efficient than traditional carving methods

The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni

Natural selection acts on all organisms, including parasites, to maximise reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment. Schistosomiasis control programmes rely on mass drug administration to reduce human morbidity and mortality. Although hotspots of reduced drug efficacy have been reported, resistance is not widespread. Using Bayesian State-Space Models (SSMs) fitted to data from an in vivo laboratory system, we tested the hypothesis that the spread of resistant Schistosoma may be limited by life-history costs not present in susceptible counterparts. Schistosoma mansoni parasites from a praziquantel–susceptible (S), a praziquantel–resistant (R) or a mixed line of originally resistant and susceptible parasites (RS) were exposed to a range of praziquantel doses. Parasite numbers at each life stage were quantified in their molluscan intermediate and murine definitive hosts across four generations, and SSMs were used to estimate key life-history parameters for each experimental group over time. Model outputs illustrated that parasite adult survival and fecundity in the murine host decreased across all lines, including R, with increasing drug pressure. Trade-offs between adult survival and fecundity were observed in all untreated lines, and these remained strong in S with praziquantel pressure. In contrast, trade-offs between adult survival and fecundity were lost under praziquantel pressure in R. As expected, parasite life-history traits within the molluscan host were complex, but trade-offs were demonstrated between parasite establishment and cercarial output. The observed trade-offs between generations within hosts, which were modified by praziquantel treatment in the R line, could limit the spread of R parasites under praziquantel pressure. Whilst such complex life-history costs may be difficult to detect using standard empirical methods, we demonstrate that SSMs provide robust estimates of life history parameters, aiding our understanding of costs and trade-offs of resistant parasites within this system and beyond

Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus

Due to the poor-fidelity of the enzymes involved in RNA genome replication, foot-and-mouth disease (FMD) virus samples comprise of unique polymorphic populations. In this study, deep sequencing was utilised to characterise the diversity of FMD virus (FMDV) populations in 6 infected cattle present on a single farm during the series of outbreaks in the UK in 2007. A novel RT–PCR method was developed to amplify a 7.6 kb nucleotide fragment encompassing the polyprotein coding region of the FMDV genome. Illumina sequencing of each sample identified the fine polymorphic structures at each nucleotide position, from consensus level changes to variants present at a 0.24% frequency. These data were used to investigate population dynamics of FMDV at both herd and host levels, evaluate the impact of host on the viral swarm structure and to identify transmission links with viruses recovered from other farms in the same series of outbreaks. In 7 samples, from 6 different animals, a total of 5 consensus level variants were identified, in addition to 104 sub-consensus variants of which 22 were shared between 2 or more animals. Further analysis revealed differences in swarm structures from samples derived from the same animal suggesting the presence of distinct viral populations evolving independently at different lesion sites within the same infected animal

Driving improvements in emerging disease surveillance through locally-relevant capacity strengthening

Emerging infectious diseases (EIDs) threaten the health of people, animals, and crops globally, but our ability to predict their occurrence is limited. Current public health capacity and ability to detect and respond to EIDs is typically weakest in low- and middle-income countries (LMICs). Many known drivers of EID emergence also converge in LMICs. Strengthening capacity for surveillance of diseases of relevance to local populations can provide a mechanism for building the cross-cutting and flexible capacities needed to tackle both the burden of existing diseases and EID threats. A focus on locally relevant diseases in LMICs and the economic, social, and cultural contexts of surveillance can help address existing inequalities in health systems, improve the capacity to detect and contain EIDs, and contribute to broader global goals for development

The impact of within-herd genetic variation upon inferred transmission trees for foot-and-mouth disease virus

Full-genome sequences have been used to monitor the fine-scale dynamics of epidemics caused by RNA viruses. However, the ability of this approach to confidently reconstruct transmission trees is limited by the knowledge of the genetic diversity of viruses that exist within different epidemiological units. In order to address this question, this study investigated the variability of 45 foot-and-mouth disease virus (FMDV) genome sequences (from 33 animals) that were collected during 2007 from eight premises (10 different herds) in the United Kingdom. Bayesian and statistical parsimony analysis demonstrated that these sequences exhibited clustering which was consistent with a transmission scenario describing herd-to-herd spread of the virus. As an alternative to analysing all of the available samples in future epidemics, the impact of randomly selecting one sequence from each of these herds was used to assess cost-effective methods that might be used to infer transmission trees during FMD outbreaks. Using these approaches, 85% and 91% of the resulting topologies were either identical or differed by only one edge from a reference tree comprising all of the sequences generated within the outbreak. The sequence distances that accrued during sequential transmission events between epidemiological units was estimated to be 4.6 nucleotides, although the genetic variability between viruses recovered from chronic carrier animals was higher than between viruses from animals with acute-stage infection: an observation which poses challenges for the use of simple approaches to infer transmission trees. This study helps to develop strategies for sampling during FMD outbreaks, and provides data that will guide the development of further models to support control policies in the event of virus incursions into FMD free countries

An uncertainty principle for star formation -- III. The characteristic emission time-scales of star formation rate tracers

We recently presented a new statistical method to constrain the physics of star formation and feedback on the cloud scale by reconstructing the underlying evolutionary timeline. However, by itself this new method only recovers the relative durations of different evolutionary phases. To enable observational applications, it therefore requires knowledge of an absolute 'reference time-scale' to convert relative time-scales into absolute values. The logical choice for this reference time-scale is the duration over which the star formation rate (SFR) tracer is visible because it can be characterised using stellar population synthesis (SPS) models. In this paper, we calibrate this reference time-scale using synthetic emission maps of several SFR tracers, generated by combining the output from a hydrodynamical disc galaxy simulation with the SPS model SLUG2. We apply our statistical method to obtain self-consistent measurements of each tracer's reference time-scale. These include H${\alpha}$ and 12 ultraviolet (UV) filters (from GALEX, Swift, and HST), which cover a wavelength range 150-350 nm. At solar metallicity, the measured reference time-scales of H${\alpha}$ are ${4.32^{+0.09}_{-0.23}}$ Myr with continuum subtraction, and 6-16 Myr without, where the time-scale increases with filter width. For the UV filters we find 17-33 Myr, nearly monotonically increasing with wavelength. The characteristic time-scale decreases towards higher metallicities, as well as to lower star formation rate surface densities, owing to stellar initial mass function sampling effects. We provide fitting functions for the reference time-scale as a function of metallicity, filter width, or wavelength, to enable observational applications of our statistical method across a wide variety of galaxies.Comment: 24 pages, 18 figures, 7 tables (including Appendices); published in MNRA

Failure of vaccination to prevent outbreaks of foot-and-mouth disease

Outbreaks of foot-and-mouth disease persist in dairy cattle herds in Saudi Arabia despite revaccination at intervals of 4-6 months. Vaccine trials provide data on antibody responses following vaccination. Using this information we developed a mathematical model of the decay of protective antibodies with which we estimated the fraction of susceptible animals at a given time after vaccination. The model describes the data well, suggesting over 95% take with an antibody half-life of 43 days. Farm records provided data on the time course of five outbreaks. We applied a 'SLIR' epidemiological model to these data, fitting a single parameter representing disease transmission rate. The analysis provides estimates of the basic reproduction number R(0), which may exceed 70 in some cases. We conclude that the critical intervaccination interval which would provide herd immunity against FMDV is unrealistically short, especially for heterologous challenge. We suggest that it may not be possible to prevent foot-and-mouth disease outbreaks on these farms using currently available vaccines

Peas Please: Making a pledge for more veg

Research suggests that eating vegetables benefits both human health and the environment. However, in the UK, very few people are eating enough vegetables. This is contributing to the global burden of diet‐related disease and associated costs, as well as undermining the possibility of a sustainable UK food system. The Peas Please initiative was launched in 2017 to encourage organisations and businesses across the food system to pledge their commitment to helping the British public increase their vegetable consumption. Since the implementation of the Peas Please initiative 95 organisations have pledged to support Peas Please and, at the time of writing, an additional 89.9 million portions of vegetables have been grown, served and sold by pledgers. This article describes the Peas Please initiative and its rationale, highlights some of the key outcomes of the programme, and outlines next steps for increasing commitment to the programme